منابع مشابه
Preparation, Characterization and in vivo Evaluation of Parenteral Sustained Release Microsphere Formulation of Zopiclone
The aim of this study was to prepare zopiclone-loaded polycaprolactone microspheres by emulsion solvent evaporation technique with different drug-to-carrier ratios {MP 1 (1:1), MP 2 (1:2), MP 3 (1:3), and MP 4 (1:4)}, characterize and evaluate the in vivo performance. The microspheres were characterized for particle size, surface morphology, drug excipient compatibility, percentage yield, drug ...
متن کاملZopiclone use during pregnancy.
QUESTION One of my patients, whom I had treated with a 2-week course of zopiclone for insomnia, conceived while using the medication. She is concerned. How should I advise her? ANSWER Based on available, albeit limited, evidence, zopiclone does not appear to be a major human teratogen.
متن کاملTwo cases of fatal zopiclone overdose.
Two cases of death due to the ingestion of zopiclone are presented. Quantitative determinations of zopiclone yielded 1.4-3.9 mg/L in the blood, 0.81 and 8.7 mg/kg in the liver, and 13.5 and 133 mg in the stomach contents. Drug concentrations were interpreted relative to the case findings, published data, and a limited evaluation of therapeutic concentrations found in two cases of therapeutic zo...
متن کاملZopiclone, a third generation of hypnotics.
Many years ago now the benzodiaze-pines began to replace the barbiturates, but, when we think about this change and remember that the barbiturates were probably being used in unnecessarily high doses, the therapeutic advantage of the benzodiaze-pines may not have been so great as it appeared at the time. The major advance was that of increased safety in overdosage. Initially, the benzodiazepine...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2008
ISSN: 0250-474X
DOI: 10.4103/0250-474x.40342